Dehydroepiandrosterone (DHEA) is a hormone that your physique naturally makes in the adrenal gland. DHEA helps create other hormones, such as testosterone and estrogen. Organic DHEA degrees peak in early adulthood and then little by little fall as you age.

A artificial model of DHEA is accessible as a tablet, capsule, powder, topical cream and gel.

Individuals use DHEA as an anti-ageing remedy and to make improvements to actual physical functionality. DHEA is also utilised to handle melancholy and indicators of menopause.


Research on DHEA for particular situations contains:

  • Growing old. In concept, getting DHEA nutritional supplements to preserve DHEA degrees could gradual the ageing approach, probably enhancing well-getting, cognitive functionality and physique composition. But so significantly study hasn’t proved this to be accurate. Much more scientific studies are wanted to far better fully grasp irrespective of whether DHEA supplementation can counteract some of the results of ageing. A modest review prompt that getting DHEA nutritional supplements may well make improvements to skin hydration and firmness, and reduce ageing places in elderly grownups.
  • Melancholy. DHEA may well be much more successful at treating melancholy than placebo, particularly in people today with lower DHEA degrees.
  • Osteoporosis. Study conclusions on the results of DHEA supplementation in the therapy of osteoporosis are blended. Much more study is wanted to figure out irrespective of whether getting DHEA nutritional supplements enhances bone density in more mature grownups with lower DHEA.
  • Vaginal atrophy. Limited study indicates that DHEA may well make improvements to vaginal dryness in postmenopausal ladies.

Research on the results of DHEA on muscle power and actual physical functionality had blended effects, but most scientific studies indicate DHEA supplementation has no influence on muscle power in more youthful or more mature grownups. The Nationwide Collegiate Athletic Affiliation has banned DHEA use between athletes.

DHEA may well eventually confirm to have gains in treating people today diagnosed with certain situations, this sort of as adrenal insufficiency and lupus. Nonetheless, further scientific studies are wanted.

Scientific studies have revealed high-quality management of this complement to frequently be lower.

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Red light: Avoid

Keep away from

Whilst some study indicates that DHEA may well be a little valuable in treating melancholy and vaginal atrophy, you can find very little evidence to assist anti-ageing claims. Also, DHEA use can bring about major side results. Keep away from utilizing this complement.

Safety and side results

DHEA is a hormone. Use of this complement may well boost degrees of androgen and have a steroid influence. DHEA also may well boost the risk of hormone-sensitive cancers, such as prostate, breast and ovarian cancers. If you have any type of cancer or are at risk of cancer, will not use DHEA.

Do not use DHEA if you happen to be pregnant or breastfeeding.

Think about avoiding use of DHEA if you have large cholesterol or a affliction that influences the source of blood to the heart (ischemic heart condition). DHEA may well lessen large-density lipoprotein (HDL), or “very good,” cholesterol degrees.

Use of DHEA also may well worsen psychiatric disorders and boost the risk of mania in people today who have temper disorders.

DHEA also may well bring about oily skin, acne and undesirable, male-sample hair growth in ladies (hirsutism).


Doable interactions consist of:

  • Antipsychotics. Use of DHEA with antipsychotics this sort of as clozapine (Clozaril, Versacloz, other folks) may well lessen the drug’s usefulness.
  • Carbamazepine (Tegretol, Carbatrol, other folks). Use of DHEA with this drug utilised to handle seizures, nerve agony and bipolar dysfunction may well lessen the drug’s usefulness.
  • Estrogen. Do not use DHEA with estrogen. Combining DHEA and estrogen may well bring about indicators of excessive estrogen, this sort of as nausea, headache and sleeplessness.
  • Lithium. Use of DHEA with lithium may well lessen the drug’s usefulness.
  • Selective serotonin reuptake inhibitors. Use of DHEA with this sort of antidepressant may well bring about manic indicators.
  • Testosterone. Do not use DHEA with testosterone. Combining DHEA and testosterone may well bring about indicators this sort of as lower sperm rely and enlarged breasts in males (gynecomastia) and the enhancement of usually male traits in ladies.
  • Triazolam (Halcion). Utilizing DHEA with this sedative may well boost the results of this drug, leading to excessive sedation and impacting your breathing and heart fee.
  • Valproic acid. Use of DHEA with this medicine utilised to handle seizures and bipolar dysfunction may well lessen the drug’s usefulness.